Lewis acid assisted reactions of N-(α- aminoalkyl)benzotriazoles and unactivated alkenes for the facile synthesis of 4-, 2,4-, and 3,4-substituted 1,2,3,4-tetrahydroquinolines
✍ Scribed by Alan R. Katritzky; Daniel A. Nichols; Ming Qi; Baozhen Yang
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1997
- Tongue
- English
- Weight
- 293 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-152X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A range of substituted tetrahydroquinolines have been synthesized from benzotriazole derivatives and unactivated alkenes in the presence of a Lewis acid. These reactions utilize readily available starting materials and mild reaction conditions, and give high yields. The reaction mechanisms are discussed.
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## Abstract 4‐__N__,__N__‐Dimethylamino‐ and 4‐cycloamino‐5‐phenyl‐1,2,4‐triazole‐3‐thiones **1–13** have been synthesized from benzhydrazides and substituted methyl dithiocarbazates under various conditions including short microwave irradiations. The last method seemed faster than the classical re