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Levuglandin E2 inhibits mitosis and microtubule assembly

โœ Scribed by K.K. Murthi; R.G. Salomon; H. Sternlicht


Book ID
119051103
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
618 KB
Volume
39
Category
Article
ISSN
0090-6980

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Microtubule drugs, which block cell cycle progression through mitosis, have seen widespread use in cancer chemotherapies. Although microtubules are subject to regulation by signal transduction mechanisms, their pharmacological modulation has so far relied on compounds that bind to the tubulin subuni