Levosimendan, a New Calcium-Sensitizing Inotrope for Heart Failure
โ Scribed by Tien M. H. Ng
- Book ID
- 115048911
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 158 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0277-0008
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๐ SIMILAR VOLUMES
Objective: Levosimendan in a new inodilator drug that sensitises troponin C in heart muscle cells to calcium, thus improving contractility. In previous studies, a single 2 mg intravenous dose of levosimendan increased cardiac output (CO) in healthy volunteers by about 40% and decreased pulmonary cap
## Interventions that augment the contractile state of the heart are associated with, or caused by, alterations in Ca 2รท exchange in heart muscles. New inotropic agents have been developed that increase the sensitivity of the myofilaments to Ca 2+. To examine the effect of calcium-sensitizing agen