Is levodopa toxic to human substantia ni
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Dr. A. H. Rajput; M. E. Fenton; S. Birdi; R. Macaulay
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Article
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1997
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John Wiley and Sons
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English
โ 506 KB
## Abstract Levodopa (LD) is the most effective drug for symptomatic control of Parkinson's disease, but has been suspected to be toxic to substantia nigra (SN) dopaminergic neurons. Tissue culture and animal studies of LD toxicity have produced contradictory evidence, and one study reported that a