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Levetiracetam in primary orthostatic tremor: A double-blind placebo-controlled crossover study

✍ Scribed by Helge Hellriegel; Jan Raethjen; G. Deuschl; Jens Volkmann

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
314 KB
Volume
26
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background:

In a double‐blind crossover study we evaluated the antitremor effect of a 4‐week treatment with either escalating dosages of levetiracetam or placebo in orthostatic tremor.

Methods:

Twelve patients with orthostatic tremor participated in the study. Primary end point was improvement in stance duration. Secondary end points were total track length of the sway path and tremor total power. The patients' impression of impairment was assessed by a visual analog scale and quality of life by the SF‐36.

Results:

We found no significant effect of dosage or treatment on stance duration (P = .175), total track length (P = .690), total power (P = .280), or visual analog scale (P =.735). Neither was SF‐36 differentially changed by levetiracetam or placebo (SF‐36, Physical Component Summary: P = .079; SF‐36, Mental Component Summary: P = .073). Side effects like dizziness, fatigue, or nausea were only mild to moderate.

Conclusions:

Levetiracetam is ineffective in the treatment of orthostatic tremor. © 2011 Movement Disorder Society

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