Level of skeletal muscle glucose transporter protein correlates with insulin-stimulated whole body glucose disposal in man

✍ Scribed by L. I. Koranyi; R. E. Bourey; H. Vuorinen-Markkola; V. A. Koivisto; M. Mueckler; M. A. Permutt; H. Yki-Järvinen

• Publisher: Springer
• Year: 1991
• Tongue: English
• Weight: 342 KB
• Volume: 34
• Category: Article
• ISSN: 0012-186X
• DOI: 10.1007/bf00401526

✦ Synopsis

The content of GLUT4 glucose transporter mRNA and protein were measured in samples of the vastus lateralis muscle of normal volunteers subjected to a 4-h hyperinsulinaemic, euglycaemic clamp. Plasma glucose concentration was clamped at 5.3 _+ 0.1 mmol/1, and serum insulin concentration was maintained at740 + 5 pmol/1. Whole body glucose uptake averaged 38.3 _+ 2.2 gmol. kg 1. min ~, 62 % of this being due to disposal via non-oxidative pathways. A significant correlation existed between basal levels of GLUT4 protein and the rate of whole body glucose disposal (r = 0.77, p < 0.02) and non-oxidative glucose disposal (r = 0.80,p < 0.02). There was no correlation between GLUT4 protein content and oxidative glucose disposal (r = 0.08, NS). These observations are consistent with an important role for skeletal muscle GLUT4 protein in whole body glucose disposal.