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Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells

โœ Scribed by Catherine A. O'Brian; Dominic Fan; Nancy E. Ward; Christopher Seid; Isaiah J. Fidler


Book ID
115921618
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
273 KB
Volume
246
Category
Article
ISSN
0014-5793

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This report shows that N-acylation of the protein kinase C (PKC) substrate Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu (RKRTLRRL) provides it with a potent inhibitory activity against PKC. N-myristoyl-RKRTLRRL inhibited Ca2(+)- and phosphatidylserine (PS)-dependent histone phosphorylation catalyzed by PKC with