A novel N-myristylated synthetic octapep
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Catherine A. O'Brian; Nancy E. Ward; Rob M. Liskamp; Dries B. Bont; Laura E. Ear
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Article
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1991
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Springer US
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English
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This report shows that N-acylation of the protein kinase C (PKC) substrate Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu (RKRTLRRL) provides it with a potent inhibitory activity against PKC. N-myristoyl-RKRTLRRL inhibited Ca2(+)- and phosphatidylserine (PS)-dependent histone phosphorylation catalyzed by PKC with