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Leukotriene B4 binding to human neutrophils

✍ Scribed by Alice H. Lin; Patricia L. Ruppel; Robert R. Gorman

Book ID
119049674
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
685 KB
Volume
28
Category
Article
ISSN
0090-6980

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## Abstract Leukotrene (LT) B~4~ activates human polymorphonuclear neutrophils. (PMN) by binding to plasmalemmal receptors. It stimulates PMN to raise cytosolic calcium and degranulate. Both responses end within 15–30 sec. However, in < 15 sec, LTB~4~‐treated PMN lose the ability to respond further