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Leukocyte mitochondrial DNA copy number in bipolar disorder

✍ Scribed by de Sousa, Rafael T.; Uno, Miyuki; Zanetti, Marcus V.; Shinjo, Sueli M.O.; Busatto, Geraldo F.; Gattaz, Wagner F.; Marie, Sueli K.N.; Machado-Vieira, Rodrigo

Book ID: 123376433
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 270 KB
Volume: 48
Category: Article
ISSN: 0278-5846
DOI: 10.1016/j.pnpbp.2013.09.002

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Mitochondrial disorders are complex and heterogeneous diseases that may be caused by molecular defects in either the nuclear or mitochondrial genome. The biosynthesis and maintenance of the integrity of the mitochondrial genome is solely dependent on a number of nuclear proteins. Defects in these nu