Leukocyte-endothelial adhesion and angiogenesis in tumors

✍ Scribed by Rakesh K. Jain; Gerald C. Koenig; Marc Dellian; Dai Fukumura; Lance L. Munn; Robert J. Melder

• Book ID: 104773348
• Publisher: Springer
• Year: 1996
• Tongue: English
• Weight: 575 KB
• Volume: 15
• Category: Article
• ISSN: 0167-7659
• DOI: 10.1007/bf00437472

✦ Synopsis

Leukocyte-endothelial adhesion and angiogenesis, until recently considered as separate processes, have been shown to be linked by two recent findings: soluble cellular adhesion molecules (CAMs) involved in leukocyte-endothelial interactions are angiogenic and well known angiogenic molecules secreted by cancer or immune. cells can modulate the endothelial CAMs. This molecular link may partially explain why the overall leukocyte-endothelial interaction is often low and heterogeneous in angiogenic tumor vessels and why activated lymphocytes adhere nonuniformly to tumor vessels when injected into the tumor's blood supply.