## BACKGROUND. The objective of the current study was to analyze the impact of adjuvant chemotherapy in comparison with other prognostic parameters on the outcome of a series of patients with breast carcinoma at time of metastatic recurrence. ## METHODS. Data from 1430 patients accrued in 8 pro
Leukemogenic effect of chemotherapy in patients with breast carcinoma : Is it a real concern?
β Scribed by Nuhad K. Ibrahim
- Book ID
- 102103706
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 48 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
β¦ Synopsis
The data presented by Kaplan and colleagues in the current issue of Cancer do not appear to be sufficiently mature to suggest the absence of an association between agents used in the treatment of breast carcinoma and the development of secondary leukemia. The updating of these data over an adequate followβup period may prove critical to the conclusions that are drawn. In addition, stratification of data according to accepted risk factors for secondary leukemia is warranted.
See pages 1529β36.
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## Abstract ## BACKGROUND The appropriate use of adjuvant chemotherapy for elderly women with breast carcinoma remains controversial. Efficacy data in women age β₯ 70 years are scarce, resulting in a lack of clear guidelines for patients in this age group. Although several studies have demonstrated
BACKGROUND. This prospective trial was conducted to evaluate the outcome of patients treated with preoperative and postoperative chemotherapy, mastectomy, and irradiation for locoregionally advanced breast carcinoma. ## METHODS. Between June 1986 and September 1990, 71 patients received 2 cycles