Although a number of cytokines have been implicated in tissue regeneration, it is unknown which ones actually function in vivo. Here, we use mice with a targeted mutation in the leukemia inhibitory factor (LIF) gene to examine the role of LIF in muscle regeneration. Using a muscle crush model, we sh
Leukemia inhibitory factor enhances regeneration in skeletal muscles after myoblast transplantation
โ Scribed by Jason D. White; John J. Bower; John B. Kurek; Lawrie Austin
- Book ID
- 102534445
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 175 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0148-639X
- DOI
- 10.1002/mus.1057
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The cytokine leukemia inhibitory factor (LIF) favors the survival and growth of axons in vitro and in vivo. Fibronectin has been shown to enhance nerve regeneration when added in combination with various growth factors including LIF. The goal of this study was to evaluate the effect of LIF plus fibr
The effects of leukemia inhibitory factor (LIF) on muscle atrophy and the reinnervation of muscle were investigated. The rat medial gastrocnemius (MG) nerve was either cut (denervation groups), crushed (reinnervation group) or left intact (normal group). Muscles were injected with LIF in phosphate b