Leukemia characterized by multiple sub-clones with unbalanced translocations involving different telomeric segments: Case report and review of the literature
✍ Scribed by Caroline A. Shippey; Mark Layton; Dr. Lorna M. Secker-Walker
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 380 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1045-2257
No coin nor oath required. For personal study only.
✦ Synopsis
A 68-year-old man presented with t(4; I l)(q2 l;q23), B-lineage acute lymphoblastic leukemia (ALL) which was negative for C-ALL antigen and TdT. Clonal evolution to five different, but related karyotypes, in which chromosomal material distal either to I q I I or I q2 I was translocated to the terminal regions of 4q -, I I q. I 6q, and I9p resulted in partial or total trisomy of I q.
The patient, having achieved a short remission, died 14 weeks after diagnosis. Five reports of jumping translocations in hematological malignancies, four with B-lineage malignancy, are reviewed. One (four cases) or both (one case) of the same Iq breakpoints were consistently found and I I q and 16q were repeatedly involved. Such cases, having multiple subclones with trisomy I q, may form a distinct subgroup of ALL.