✦ LIBER ✦

Leukaemomycin, an antibiotic with antitumor activity. I. Screening, fermentation, and biological activity

✍ Scribed by Dr. habil. W. Fleck; D. Strauss

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 719 KB
Volume: 15
Category: Article
ISSN: 0233-111X
DOI: 10.1002/jobm.19750150703

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A Streptomyces strain belonging to S. griseus (KRAINSKI) WAKSMAN et HENRICI 1948 sensu HÜTER (1967) was found to produce an antitumor antibiotic designated as leukaemomycin. The red‐pigment antibiotic, having antimicrobial and antitumor activity in vitro and in vivo, was isolated from C‐, N‐, and Fe‐containing cultures of the strains IMET JA 3933, IMET JA 5570, IMET JA 10086, and IMET JA 10431. Leukaemomycin has indicator properties and is produced by the classic procedures of submerged fermentation. The crude base of leukaemomycin consists of 4 main components, designated as leukaemomycin A, B, C, and D. The biological acitivity of the main components leukaemomycin B and C was compared. The biological activity and the physicochemical properties of leukaemomycin C are identical with known properties of the anthracycline antibiotic daunorubicin.

📜 SIMILAR VOLUMES

Leukaemomycin, an antibiotic with antitu

Leukaemomycin, an antibiotic with antitumor activity. II. Isolation and identification

✍ Dr. D. Strauss; W. Fleck 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 612 KB

## Abstract A __Streptomyces__ strain belonging to __Streptomyces griseus__ (KRAINSKY) WAKSMAN __et__ Henrici 1948 __sensu__ HÜTTER (1967) was found to produce the red‐pigment antibiotic leukaemomycin. The antitumor active antibiotic was isolated from the culture broth and purified by ion‐exchange

ChemInform Abstract: UCE6, a New Antitum

ChemInform Abstract: UCE6, a New Antitumor Antibiotic with Topoisomerase I-Mediated DNA Cleavage Activity Produced by Actinomycetes: Producing Organism, Fermentation, Isolation and Biological Activity

✍ N. FUJII; F. TANAKA; Y. YAMASHITA; T. ASHIZAWA; S. CHIBA; H. NAKANO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 2 views

Korkormicins, novel depsipeptide antitum

Korkormicins, novel depsipeptide antitumor antibiotics fromMicromonosporasp C39500: Fermentation, precursor directed biosynthesis and biological activities

✍ K S Lam; D R Gustavson; G A Hesler; T T Dabrah; J A Matson; R L Berry; W C Rose; 📂 Article 📅 1995 🏛 Springer-Verlag 🌐 English ⚖ 555 KB

ChemInform Abstract: TMC-69, a New Antit

ChemInform Abstract: TMC-69, a New Antitumor Antibiotic with Cdc25A Inhibitory Activity, Produced by Chrysosporium sp. TC1068. Taxonomy, Fermentation and Biological Activities.

✍ Naomitsu Hirano; Jun Kohno; Shiho Tsunoda; Maki Nishi; Noboru Kishi; Toru Okuda; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 26 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: UCH9, a New Antitum

ChemInform Abstract: UCH9, a New Antitumor Antibiotic Produced by Streptomyces. Part 1. Producing Organism, Fermentation, Isolation, and Biological Activities.

✍ H. OGAWA; Y. YAMASHITA; R. KATAHIRA; S. CHIBA; T. IWASAKI; T. ASHIZAWA; H. NAKAN 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 25 KB 👁 2 views

Oximidine III, a New Antitumor Antibioti

Oximidine III, a New Antitumor Antibiotic Against Transformed Cells from Pseudomonas sp. Part 1. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activity.

✍ Yoichi Hayakawa; Taijiro Tomikawa; Kazuo Shin-Ya; Nakako Arao; Koji Nagai; Ken-i 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 63 KB 👁 2 views