Leukaemia inhibitory factor prevents loss of p75-nerve growth factor receptor immunoreactivity in medial septal neurons following fimbria–fornix lesions

Reducing p75 nerve growth factor recepto

Reducing p75 nerve growth factor receptor levels using antisense oligonucleotides prevents the loss of axotomized sensory neurons in the dorsal root ganglia of newborn rats

✍ S.S. Cheema; G.L. Barrett; P.F. Bartlett 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 860 KB

The low-affinity p75 receptor for nerve growth factor (p75NGFR) has been implicated in mediating neuronal cell death in vitro. A recent in vitro study from our laboratory showed that the death of sensory neurons can be prevented by reducing the levels of p75NGFR with antisense oligonucleotides. To d