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Leucoderma associated with flares of erythrodermic cutaneous T-cell lymphomas: four cases

✍ Scribed by A. Bouloc; F. Grange; M.H. Delfau-Larue; M.T. Dieng; M.C. Tortel; M.F. Avril; J. Revuz; M. Bagot; J. Wechsler; For The French Study Group Of Cutaneous Lymphomas

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 643 KB
Volume: 143
Category: Article
ISSN: 0007-0963
DOI: 10.1046/j.1365-2133.2000.03851.x

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✦ Synopsis

We describe four patients with erythrodermic cutaneous T-cell lymphomas (two with erythrodermic mycosis fungoides, and two with Sézary syndrome) who presented with extensive hypopigmented lesions that occurred during flares of their cutaneous disease. These cases must be distinguished from previously described hypopigmented mycosis fungoides where hypopigmented lesions were the sole manifestation of the lymphoma. In two cases a biopsy was performed on hypopigmented skin, showing an infiltrate of atypical lymphocytes with epidermotropism and absence of melanocytes, as in vitiligo. It is suggested that the hypopigmentation could be due to the cytotoxicity of tumour or reactional lymphocytes directed against melanocytes.

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