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Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway

✍ Scribed by Tomoaki Tomiya; Takako Nishikawa; Yukiko Inoue; Natsuko Ohtomo; Hitoshi Ikeda; Kazuaki Tejima; Naoko Watanabe; Yasushi Tanoue; Masao Omata; Kenji Fujiwara


Book ID
116294874
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
196 KB
Volume
358
Category
Article
ISSN
0006-291X

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## Abstract The essential amino acid leucine has been described to specifically activate signaling pathways leading to the activation of the translational machinery and the increase of total protein synthesis. Regulation of type I collagen production by hepatic stellate cells (HSC) is a multistep p