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Leucine-rich repeat proteins of synapses

✍ Scribed by Jaewon Ko; Eunjoon Kim

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
211 KB
Volume
85
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Leucine‐rich repeats (LRRs) are 20–29‐aa motifs that mediate protein–protein interactions and are present in a variety of membrane and cytoplasmic proteins. Many LRR proteins with neuronal functions have been reported. Here, we summarize an emerging group of synaptic LRR proteins, which includes densin‐180, Erbin, NGL, SALM, and LGI1. These proteins have been implicated in the formation, differentiation, maintenance, and plasticity of neuronal synapses. © 2007 Wiley‐Liss, Inc.

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