The Roc domain of leucine-rich repeat ki
β
Payal N. Gandhi; Xinglong Wang; Xiongwei Zhu; Shu G. Chen; Amy L. Wilson-Delfoss
π
Article
π
2008
π
John Wiley and Sons
π
English
β 399 KB
## Abstract Mutations in the __leucineβrich repeat kinase 2__ (__LRRK2__) gene are the leading cause of genetically inherited Parkinson's disease (PD). Although this multidomain protein has been shown to have both GTPase and kinase activities through the Roc and MAPKKK domains, respectively, the pr