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Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration

✍ Scribed by Caesar, Mareike; Zach, Susanne; Carlson, Coby B.; Brockmann, Kathrin; Gasser, Thomas; Gillardon, Frank


Book ID
122728093
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
739 KB
Volume
54
Category
Article
ISSN
0969-9961

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## Abstract Mutations in the __leucine‐rich repeat kinase 2__ (__LRRK2__) gene are the leading cause of genetically inherited Parkinson's disease (PD). Although this multidomain protein has been shown to have both GTPase and kinase activities through the Roc and MAPKKK domains, respectively, the pr