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Leucine enkephalin analogues containing a conformationally restrained N-terminal amino acid residue

✍ Scribed by Roger D. Waigh; Trevor Deeks; Peter A. Crooks


Book ID
102916173
Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
515 KB
Volume
73
Category
Article
ISSN
0022-3549

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Studies on Amino Acids and Peptides, 11.
✍ Andersen, Torben P. ;Senning, Alexander πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 608 KB

The newly synthesized amino acid (S)-5-thioxoproline ((sj-Top OH) (1) has been coupled with HCI \* H-(S)-Leu-GlyNRR 6 by the mixed anhydride method. The resulting tripeptide amides (Sy-Top-(Sf-Leu-GlyNRR' 7 are new analogues of the hypothalamic factor MIF. The intermediatcs 6 were synthesiirzd by am