LETTER TO THE EDITOR. LOW VERSUS HIGH CELL TURNOVER IN DIFFUSELY GROWING NON-HODGKIN'S LYMPHOMAS

✍ Scribed by YAVORKOVSKY, LEONID L.

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 109 KB
• Volume: 180
• Category: Article
• ISSN: 0022-3417
• DOI: 10.1002/(sici)1096-9896(199611)180:3<350::aid-path666>3.0.co;2-2

✦ Synopsis

high PI of a tumour is in itself a result of a later genetic event following initial transformation-a phenomenon of tumour progression at presentation. The role of proliferation parameters in predicting tumour behaviour has been contr~versial.~,~ However, assessment of turnover index could prove to be useful in predicting the behaviour of tumours of similar histology and grade. Its predictive value would be best when tumours of similar volume, or patients in the same pathological stage, are compared. The volume of a tumour is better measured in solid tumours and hence it may prove to be more beneficial. In haemato-lymphoid malignancies, it may be better to use the turnover index to compare patients of similar stage.