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Letter in response to “Identifying Lynch syndrome” by de la Chapelle et al.

✍ Scribed by Mark A. Jenkins; James G. Dowty; John L. Hopper; Kathy Tucker; Melissa C. Southey


Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
92 KB
Volume
126
Category
Article
ISSN
0020-7136

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✦ Synopsis


Abstract

No abtract.


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✍ Hidewaki Nakagawa; Heather Hampel; Albert de la Chapelle 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 201 KB 👁 2 views

It has recently been suggested that large genomic rearrangements account for 10-20% of all MSH2 mutations, and a lower proportion of all MLH1 mutations, among individuals with Lynch syndrome (hereditary non-polyposis colorectal cancer, HNPCC). These rearrangements are notoriously difficult to detect