๐”– Bobbio Scriptorium
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Letrozole (CGS 20267). A phase I study of a new potent oral aromatase inhibitor of breast cancer

โœ Scribed by Allan Lipton; Laurence M. Demers; Harold A. Harvey; Kathleen B. Kambic; Howard Grossberg; Carolyn Brady; H. Adlercruetz; Patrick F. Trunet; Richard J. Santen


Book ID
102672642
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
663 KB
Volume
75
Category
Article
ISSN
0008-543X

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A phase I trial of CGS 16949a. A new aro
โœ Allan Lipton; Harold A. Harvey; Laurence M. Demers; John R. Hanagan; Mary T. Mul ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 632 KB

CGS 16949A is a new, nonsteroidal competitive inhibitor of the aromatase enzyme. In this Phase I trial, 16 heavily pretreated postmenopausal patients with metastatic breast cancer were treated with escalating doses of CGS 16949A from 0.6 to 16 mg total daily oral dose. No hematologic, biochemical, o