✦ LIBER ✦

Lethal chromosomal deletions in the mouse, a model system for the study of development and regulation of postnatal gene expression

✍ Scribed by Salome Gluecksohn-Waelsch; Donald Defranco

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 680 KB
Volume: 13
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950131102

No coin nor oath required. For personal study only.

✦ Synopsis

Mechanisms involved in the regulation of development and its genetic control are receiving ever-increasing attention in studies of mammalian developmental genetics. The potential success of such studies is strongly enhanced by the availability of suitable systems of analysis. Such a system was identified in a series of radiation-induced chromosomal deletions at and around the albino (c) locus of the mouse associated with cell type-specific effects on liver differentiation. Their detailed study has aided the analysis of possible mechanisms of cell type-specific gene expression. As summarized in this review, the experimental results strongly suggest that specific trans-acting developmental regulatory genes are concerned with the differentiation of hormone-inducible expression of a cluster of hepatocyte specific structural genes mapping in different parts of the genome.

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