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Lesion of serotonergic neurons antagonizes clonidine-induced suppression of avoidance behavior and locomotor activity in rats

✍ Scribed by Wojciech Kostowski; Adam Plaznik; Olgierd Pucilowski; Andrzej Bidzinski; Mirosława Hauptmann

Publisher: Springer
Year: 1981
Tongue: English
Weight: 601 KB
Volume: 73
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00422414

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✦ Synopsis

The effects of clonidine on avoidance acquisition and locomotor activity were studied in male Wistar rats with 5,6-dihydroxytryptamine (5,6-DHT) lesions of the median raphe nucleus. Lesioned animals showed marked depletion in forebrain serotonin and 5-hydroxyindole acetic acid concentrations. Clonidine (0.2 mg/kg IP in a single daily dose for 6 consecutive days) inhibited avoidance acquisition and reduced locomotor activity in unlesioned rats. In 5,6-DHT rats clonidine failed to produce depressive effects. The resistance of raphe-lesioned rats to clonidine is discussed on the basis of possible interaction between noradrenergic and serotonergic brain systems.

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