Leptomeningeal dissemination of primary central nervous system tumors of childhood
โ Scribed by Dr. Roger J. Packer; Kathy R. Siegel; Leslie N. Sutton; Phillip Litmann; Derek A. Bruce; Luis Schut
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 487 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## BACKGROUND. Topotecan is a topoisomerase I inhibitor that has good penetration across the blood-brain barrier and significant antitumor activity against human brain tumor xenografts. In a Phase I trial in children with refractory cancer, topotecan was well tolerated when administered as a 24-ho
A group of 28 consecutive patients (mean age 59 years) with primary central nervous system lymphoma (PCNSL) was treated with different regimens, including steroids only, radiotherapy (RT), chemotherapy or combinations of all. Lymphoma was classiยฎed as high grade malignant B-cell non-Hodgkin's lympho