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Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice

✍ Scribed by Naohiko Ueno; Akio Inui; Pushpa S. Kalra; Satya P. Kalra

Book ID: 116831100
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 625 KB
Volume: 27
Category: Article
ISSN: 0196-9781
DOI: 10.1016/j.peptides.2006.03.006

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## Abstract Both central and peripheral leptin administrations reduce body weight, food intake, and adiposity in __ob/ob__ mice. In this study we compared effects of intracerebroventricular (ICV) and subcutaneous (SC) administration of leptin on bone metabolism in the appendicular and axial skeleto