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Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

✍ Scribed by Kim, Jae Geun; Suyama, Shigetomo; Koch, Marco; Jin, Sungho; Argente-Arizon, Pilar; Argente, Jesús; Liu, Zhong-Wu; Zimmer, Marcelo R; Jeong, Jin Kwon; Szigeti-Buck, Klara; Gao, Yuanqing; Garcia-Caceres, Cristina; Yi, Chun-Xia; Salmaso, Natalina; Vaccarino, Flora M; Chowen, Julie; Diano, Sabrina; Dietrich, Marcelo O; Tschöp, Matthias H; Horvath, Tamas L

Book ID
124055690
Publisher
Nature Publishing Group
Year
2014
Tongue
English
Weight
713 KB
Volume
17
Category
Article
ISSN
1097-6256

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## Abstract A decade ago, leptin (from the greek lepto meaning ‘thin’) was identified as the product of the __ob__ gene.1 This adipocyte‐derived hormone was found to suppress feeding and stimulate thermogenesis, and was thus proposed as a mediator in a negative feedback loop that controls body adip