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Leptin promotes osteoblast differentiation and mineralization of primary cultures of vascular smooth muscle cells by inhibiting glycogen synthase kinase (GSK)-3β

✍ Scribed by Melec G. Zeadin; Martin K. Butcher; Stephen G. Shaughnessy; Geoff H. Werstuck

Book ID: 116303857
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 954 KB
Volume: 425
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2012.08.011

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## Abstract We have previously shown that oxidized low‐density lipoproteins (oxLDLs) act synergistically with β‐glycerophosphate to induce the osteogenic differentiation of primary bovine aortic smooth muscle cells (BASMCs). In the present study, we attempt to resolve the mechanism responsible for