## Abstract Tauopathies, including Alzheimer's disease (AD), are a group of neurodegenerative disorders characterized by the presence of intraneuronal filamentous inclusions of abnormally phosphorylated tau protein. In AD brains, it has been shown that the level of abnormally phosphorylated tau is
✦ LIBER ✦
Leptin inhibits glycogen synthase kinase-3β to prevent tau phosphorylation in neuronal cells
✍ Scribed by Steven J. Greco; Sraboni Sarkar; Gemma Casadesus; Xiongwei Zhu; Mark A. Smith; J. Wesson Ashford; Jane M. Johnston; Nikolaos Tezapsidis
- Book ID
- 116771297
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 468 KB
- Volume
- 455
- Category
- Article
- ISSN
- 0304-3940
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## Abstract The developing central nervous system (CNS) is particularly susceptible to ethanol toxicity. The loss of neurons underlies many of the behavioral deficits observed in fetal alcohol spectrum disorders (FASD). The mechanisms of ethanol‐induced neuronal loss, however, remain incompletely e