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Leptin Inhibits Bone Formation through a Hypothalamic Relay: A Central Control of Bone Mass

โœ Scribed by Patricia Ducy; Michael Amling; Shu Takeda; Matthias Priemel; Arndt F Schilling; Frank T Beil; Jianhe Shen; Charles Vinson; Johannes M Rueger; Gerard Karsenty

Book ID
117268325
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
499 KB
Volume
100
Category
Article
ISSN
0092-8674

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## Abstract Both central and peripheral leptin administrations reduce body weight, food intake, and adiposity in __ob/ob__ mice. In this study we compared effects of intracerebroventricular (ICV) and subcutaneous (SC) administration of leptin on bone metabolism in the appendicular and axial skeleto