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Leptin in relation to prostate cancer and benign prostatic hyperplasia

โœ Scribed by Pagona Lagiou; Lisa B. Signorello; Dimitrios Trichopoulos; Anastasia Tzonou; Antonia Trichopoulou; Christos S. Mantzoros

Publisher
John Wiley and Sons
Year
1998
Tongue
French
Weight
44 KB
Volume
76
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

The aim of our study was to determine whether leptin, a hormone implicated in both energy-balance and reproductive function, is involved in the etiology of prostate cancer or benign prostatic hyperplasia (BPH). We compared the serum leptin levels of 43 cases of incident prostate cancer, 41 patients with BPH, and 48 healthy controls, all recruited in Athens, Greece. Multiple logistic regression modeling was used, with adjustment for age, height, body mass index, education, estradiol, testosterone, dihydrotestosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin and insulin like growth factor 1. Odds ratios per 4 ng/ml increment of leptin were 0.70 [95% confidence interval (CI) (0.32,1.55)] for prostate cancer and 1.06 [95% CI (0.67,1.67)] for BPH. After adjustment for body mass index, serum leptin levels were not significantly correlated with levels of any of the other hormones under study. Leptin levels are unlikely to affect the risk of either prostate cancer or BPH substantially.

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