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Leptin deficiency produces contrasting phenotypes in bones of the limb and spine

โœ Scribed by M.W Hamrick; C Pennington; D Newton; D Xie; C Isales


Book ID
116318825
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
529 KB
Volume
34
Category
Article
ISSN
8756-3282

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## Abstract Both central and peripheral leptin administrations reduce body weight, food intake, and adiposity in __ob/ob__ mice. In this study we compared effects of intracerebroventricular (ICV) and subcutaneous (SC) administration of leptin on bone metabolism in the appendicular and axial skeleto