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Leptin deficiency prevents the activation of the murine α2(I) collagen promoter by acetaldehyde

✍ Scribed by James J. Potter; Lynda Rennie-Tankersley; Esteban Mezey

Book ID
116177004
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
141 KB
Volume
426
Category
Article
ISSN
0003-9861

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The mechanism whereby ethanol ingestion results in hepatic fibrosis remains unknown. Acetaldehyde has been shown to increase a,(I) collagen gene transcription in human fibroblasts and in rat myofibroblastlike cells (Ito cells) in culture. In this study, the effect of acetaldehyde was determined on t