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Leptin activates MAPK signaling in human breast and prostate cancer

✍ Scribed by L. Vona-Davis; H. Skinner; B. Jackson; D. Riggs; P. Somasundar; D.W. McFadden

Book ID
116701121
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
53 KB
Volume
114
Category
Article
ISSN
0022-4804

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## Abstract The adipocyte‐derived peptide leptin acts through binding to specific membrane receptors, of which six isoforms (obRa‐f) have been identified up to now. Binding of leptin to its receptor induces activation of different signaling pathways, including the JAK/STAT, MAPK, IRS1, and SOCS3 si