Leprosy and cell-mediated immunity

✍ Scribed by Gilla Kaplan; Zanvil A. Cohn

• Publisher: Elsevier Science
• Year: 1991
• Tongue: English
• Weight: 788 KB
• Volume: 3
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/0952-7915(91)90083-d

✦ Synopsis

The intradermal injection of the purified protein derivative of tuberculin into lepromatous leprosy patients leads to a local cell-mediated immune response and to the extensive destruction of Mycobacterium leprae. This local response also occurs after intradermal injection of recombinant human interleukin-2; when administered over an 8-day period interleukin-2 evokes a systemic cell-mediated immune response and a reduction in the bacillary burden.