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Lepadiformine: A Case Study of the Value of Total Synthesis in Natural Product Structure Elucidation

โœ Scribed by Weinreb, Steven M.

Book ID
127088475
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
178 KB
Volume
36
Category
Article
ISSN
0001-4842

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Four unknown trace impurities (7-10) were observed in the capsule formulation of the HIV drug Tipranavir ๏›š after prolonged storage at 30 โ€ข C/70% RH. Extensive NMR and LC/MS analyses revealed the compounds to be covalent adducts between TRIS, an excipient of the formulation, and diastereomeric Tipran