In 1995 Professor Kingsman co-founded Oxford BioMedica to develop and commercialise gene technologies arising out of research undertaken by the Group at the University. The company uses advanced gene delivery technologies for the treatment of disease in the areas of oncology, viral infection, neurob
Lentiviral vectors for HIV disease prevention and treatment
β Scribed by Franck Lemiale; Nikolay Korokhov
- Book ID
- 116961297
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 294 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0264-410X
No coin nor oath required. For personal study only.
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## Abstract Lentiviruses are unique in their ability to infect both dividing and nonβdividing cells. This makes the vectors derived from them particularly useful for gene transfer into nonβdividing cells, including stem cells. Lentiviral vectors are becoming the vectors of choice for si/shRNA deliv
## Abstract ## Background HIVβ1 replication can be inhibited with RNA interference (RNAi) by expression of short hairpin RNA (shRNA) from a lentiviral vector. Because lentiviral vectors are based on HIVβ1, viral sequences in the vector system are potential targets for the antiviral shRNAs. Here, w