Lenalidomide, cyclophosphamide and dexamethasone (CRd) for newly diagnosed multiple myeloma: Results from a phase 2 trial
โ Scribed by Shaji K. Kumar; Martha Q. Lacy; Suzanne R. Hayman; Keith Stewart; Francis K. Buadi; Jacob Allred; Kristina Laumann; Philip R. Greipp; John A. Lust; Morie A. Gertz; Steven R. Zeldenrust; P. Leif Bergsagel; Craig B. Reeder; Thomas E. Witzig; Rafael Fonseca; Stephen J. Russell; Joseph R. Mikhael; David Dingli; S. Vincent Rajkumar; Angela Dispenzieri
- Book ID
- 101433643
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 286 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0361-8609
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## Abstract ## BACKGROUND Patients with multiple myeloma (MM) have increased bone marrow angiogenesis, a low plasma cell labeling index, and multidrug resistance (the primary cause of chemotherapy failure). MM patients receiving the vincristine, doxorubicin, and dexamethasone (VAD) regimen develop
## Abstract ## BACKGROUND Today, intensive therapy that includes highโdose melphalan with autologous stem cell transplantation (ASCT) is considered standard therapy in younger patients with newly diagnosed myeloma. When the current trial was initiated, combined vincristine, doxorubicin, and dexame