Leishmanicidal and Trypanocidal activities of Acetogenins isolated from Annona glauca
✍ Scribed by Anne-Isabelle Waechter; Gloria Yaluff; Alba Inchausti; Antonieta Rojas de Arias; Reynald Hocquemiller; André Cavé; Alain Fournet
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 65 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
The dichloromethane extract of seeds of Annona glauca (Annonaceae) was active against three strains of Leishmania species. Nine known acetogenins were isolated and identified and then evaluated in vitro against Leishmania species and the bloodstream forms of Trypanosoma cruzi. Annonacin A and goniothalamicin showed activity against Leishmania, and glaucanisin, squamocin, annonacin A and annonacin against Trypanosoma cruzi reducing the parasites by 78%, 67%, 71% and 85%, respectively.
📜 SIMILAR VOLUMES
Seventeen extracts and seven secondary metabolites isolated from basidiomycetes were tested in medium culture against promastigote forms of Leishmania spp. and bloodstream forms of Trypanosoma cruzi. Extracts from the culture filtrate or mycelium were generally inactive against the parasites except
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