Leiomyosarcoma arising in atypical fibromuscular hyperplasia (phyllodes tumor) of the prostate with distant metastasis
✍ Scribed by Moonahm Yum; Jean C. Miller; Bharat L. Agrawal
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 647 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
An extremely rare neoplasm of the prostate, commonly known as phyllodes type of atypical prostatic hyperplasia, is described in a 57-year-old man. Over a &year period, the atypical smooth muscle component has transformed into leiomyosarcoma, and eventually metastasized to the bones and the lungs. Such an evolution has never been documented for this tumor. Cancer 68:910-915,1991.
TYPICAL FIBROMUSCULAR HYPERPLASIA Of the
A prostate is an uncommon tumor of the prostate, previously described under a variety of names, including prostatic cystosarcoma phyllodes,'--' phyllodes type of atypical prostatic hyperpla~ia,~,~ atypical stromal smooth muscle hyperplasia,6 and pseudosarcomatous lesion.' The initial presentation of these patients was related with symptoms of urinary tract obstruction, which made it difficult to distinguish from other causes of prostatism. The tumor, however, has a distinct histologic appearance as will be described below. The clinical courses of most patients were benign, although local recurrences were observed in five of the nine cases showing cytologic atypia in the stromal cells. '-' In this report we describe a 57-year-old man who initially presented with atypical fibromuscular hyperplasia of the prostate and developed a leiomyosarcoma which eventually metastasized to the lungs and bones. This is the first case in which such an evolutions is documented. We also review cases previously reported in the Englishlanguage literature.