Left–right patterning of the mouse lateral plate requires nodal produced in the node
✍ Scribed by Yukio Saijoh; Shinya Oki; Sachiko Ohishi; Hiroshi Hamada
- Book ID
- 117092887
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 812 KB
- Volume
- 256
- Category
- Article
- ISSN
- 0012-1606
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Left±right asymmetric signaling molecules in mammals include three transforming growth factor b (TGFb)-related factors, Nodal, Lefty1 and Lefty2. They are all expressed on the left half of developing mouse embryos. Nodal acts as a left-side determinant by transducing signals through Smad and FAST an
Medicine positional information. Insight into upstream events that and Department of Genetics govern asymmetric gene expression has come from 2 Department of Internal Medicine study of mouse and human mutations affecting LR deand Department of Genetics velopment, which do not represent mutations in