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Left ventricular remodeling following myocardial infarction revealed with a quantitative diffusion MRI tractography framework

✍ Scribed by Choukri Mekkaoui; Shuning Huang; Guangping Dai; Timothy G Reese; Aravinda Thiagalingam; Pal Maurovich-Horvat; Jeremy Ruskin; Udo Hoffmann; Marcel P Jackowski; David E Sosnovik

Publisher: BioMed Central
Year: 2012
Tongue: English
Weight: 218 KB
Volume: 14
Category: Article
ISSN: 1097-6647
DOI: 10.1186/1532-429x-14-s1-p35

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✦ Synopsis

A cardiac-tailored framework for 3D Diffusion Tensor MRI tractography is developed and used to characterize myofiber architecture in normal and remodeled myocardium. We show that myofibers in the subepicardium of the remote infarct zone become less oblique (more circumferential) as the heart dilates and remodels. This fiber realignment may play an important role in the loss of contractile function in the remote zone over time.

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