✦ LIBER ✦

LED-activated pheophorbide a induces cellular destruction of colon cancer cells

✍ Scribed by C.S. Xu; A.W.N. Leung; L. Liu; X.S. Xia

Book ID: 102450698
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 224 KB
Volume: 7
Category: Article
ISSN: 1612-2011
DOI: 10.1002/lapl.201010008

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✦ Synopsis

Pheophorbide a (Pa) from Chinese herbal medicine Scutellaria Barbata and Silkworm Excreta shows an important promise in the photodynamic therapy on malignant tumor. The present study investigated that LED-activated Pa induced the cellular destruction of colon cancer HT-29 cells. The results showed that Pa resulted in a drug-dose dependent photocytotoxicity in the HT-29 cells, meaning the photocytotoxicity of Pa depends on the drug concentration (0 -2 μM). We further investigated the apoptosis of the HT-29 cells 18 hours after photosensitization of Pa using a confocal laser scanning microscopy with Hoechst 33258 staining. These data demonstrated that LED-activated Pa could significantly induce the cellular destruction of the HT-29 cells.

The nuclear features in the HT-29 cells 18 hours after PDT with Pa (0.5 μM, 1 J/cm 2 ) observed using CLSM with Hoechst 33258 staining. PDT with Pa

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