The Four Volume Set Assembled Following The 2005 International Conference On Computational Science And Its Applications, Iccsa 2005, Held In Suntec International Convention And Exhibition Centre, Singapore, From 9 May 2005 Till 12 May 2005, Represents The ?ne Collection Of 540 Refereed Papers Selected From Nearly 2,700 Submissions. Computational Science Has ?rmly Established Itself As A Vital Part Of Many Scienti?c Investigations, A?ecting Researchers And Practitioners In Areas Ranging From Applications Such As Aerospace And Automotive, To Emerging Technologies Such As Bioinformatics And Nanotechnologies, To Core Disciplines Such As Ma- Ematics, Physics, And Chemistry. Due To The Shear Size Of Many Challenges In Computational Science, The Use Of Supercomputing, Parallel Processing, And - Phisticated Algorithms Is Inevitable And Becomes A Part Of Fundamental T- Oretical Research As Well As Endeavors In Emerging ?elds. Together, These Far Reaching Scienti?c Areas Contribute To Shape This Conference In The Realms Of State-of-the-art Computational Science Research And Applications, Encompassing The Facilitating Theoretical Foundations And The Innovative Applications Of Such Results In Other Areas.