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Leber's hereditary optic neuropathy triggered by antiretroviral therapy for human immunodeficiency virus

✍ Scribed by Mackey, D A; Fingert, J H; Luzhansky, J Z; McCluskey, P J; Howell, N; Hall, A J H; Pierce, A B; Hoy, J F


Book ID
110035025
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
144 KB
Volume
17
Category
Article
ISSN
0950-222X

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This report describes a rapid and inexpensive assay, which allows detection, in whole blood and by PCR alone, of the two most frequent mitochondrial DNA mutations causing Leber's hereditary optic neuropathy. The assay is based on allele-specific amplification, using primers with the mutation-specifi