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Least-squares estimation of enzyme parameters

✍ Scribed by M.E. Jones; K. Taransky

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
411 KB
Volume
21
Category
Article
ISSN
0010-4825

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✦ Synopsis

The estimation of the enzyme parameters K, and V,,,,, from initial velocity data, or of analogous parameters in binding or transport experiments may be accomplished by transformation of the data, or by a direct weighted least-squares fit. Although the latter makes better use of the data, the method is complex and may be sensitive to initial parameter estimates. We develop a method which reduces the problem to finding the zero of a continuous function of a single variable.

Non-linear least squares

Parameter estimation

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