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Learned helplessness increases 5-hydroxytryptamine1B receptor mRNA levels in the rat dorsal raphe nucleus

✍ Scribed by John F. Neumaier; Frederick Petty; Gerald L. Kramer; Patricia Szot; Mark W. Hamblin


Book ID
118510834
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
772 KB
Volume
41
Category
Article
ISSN
0006-3223

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Serotonin release from dorsal raphe projections in the forebrain is regulated by terminal 5-HT 1B autoreceptors; dysregulation of these receptors may be involved in the pathophysiology of clinical depression. Using in situ hybridization, we have previously reported that fluoxetine reduces 5-HT 1B mR