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Leader sequence is required for activity of transmembrane tumor necrosis factor-α

✍ Scribed by Fang Zheng; Na Liu; Qizheng Chen; Lin Yang; Lili Liu; Ping Xiong; Wei Feng; Xiaodan Jiang; Feili Gong; Zhuoya Li


Book ID
116757525
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
591 KB
Volume
46
Category
Article
ISSN
0161-5890

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✍ Kyoichi Shimomura; Toshitaka Manda; Sueo Mukumoto; Katsumasa Kobayashi; Kazuo Na 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 676 KB

In a previous study we showed that recombinant human tumor necrosis factor-a (rTNF-tr) has no cytolytic effect on Meth A fibrosarcoma cells in virro but that it has a strong anti-tumor activity in vivo. In the present work, we define the in vivo mode of action of rTNF-a on solid-form Meth A fibrosar