✦ LIBER ✦

Lead development: Validation and application of high throughput screening for determination of pharmacokinetic parameters for enzyme inhibitors

✍ Scribed by Jasbir Singh; Jim Soloweij; Martin Allen; Loran Killar; Mark Ator

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 430 KB
Volume: 4
Category: Article
ISSN: 0968-0896
DOI: 10.1016/0968-0896(96)00057-0

No coin nor oath required. For personal study only.

✦ Synopsis

An approach utilizing robotics (automation) for the rapid and reliable determination of protease inhibitor concentration in rat plasma samples is described. The bioassay protocol using an immobilized peptide substrate allows high sample throughput, compatible with parallel synthesis/SAR development strategy.

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